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5 Jan | Categories : Radiology Start a topic Comment Mail Share Download
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5 Jan | Categories : Pathology Start a topic Comment Mail Share Download
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5 Jan | Categories : Pathology Start a topic Comment Mail Share Download
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5 Jan | Categories : Pathology Start a topic Comment Mail Share Download
fibrosis and functional failure. There is a great need for therapies that could effectively target pathophysiological pathways involved in fibrosis. GPR40 and GPR84 are G protein–coupled receptors with free fatty acid ligands and are associated with metabolic and inflammatory disorders. Although GPR40 and GPR84 are involved in diverse physiological processes, no evidence has demonstrated the relevance of GPR40 and GPR84 in fibrosis pathways. Using PBI-4050 (3-pentylbenzeneacetic acid sodium salt), a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively, the investigator uncovered an antifibrotic pathway involving these receptors...ReadMore

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5 Jan | Categories : Pathology Start a topic Comment Mail Share Download
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2 Jan | Categories : Ophthalmology Start a topic Comment Mail Share Download
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2 Jan | Categories : Ophthalmology Start a topic Comment Mail Share Download
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2 Jan | Categories : Ophthalmology Start a topic Comment Mail Share Download
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31 Dec | Categories : General Surgery Start a topic Comment Mail Share Download
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