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21 Nov | Categories : Hematology Start a topic Comment Mail Share Download
aimed to examine the associationbetween ESA use and cardiovascular events in patients with multiple myeloma andmyelodysplastic syndrome in a large population-based cohort study...ReadMore ">


21 Nov | Categories : Hematology Start a topic Comment Mail Share Download
Globally, sickle cell disease (SCD) is one ofthe most common haemoglobinopathy. Considered a public health problem, it leadsto vessel occlusion, blood stasis and chronic activation of the coagulationsystem responsible for vaso-occlussive crises and venous thromboembolism (VTE)which may be fatal.  A systematic reviewand meta-analysis was conducted to summarize existing evidence on the risk ofVTE in people with SCD or sickle trait (SCT)...ReadMore">


21 Nov | Categories : Hematology Start a topic Comment Mail Share Download
The presence of anaemia in chronic kidneydisease further increases the risk of left ventricular hypertrophy andoxidative stress, thereby magnifying the deleterious consequence in uraemiccardiomyopathy (UCM), and aggravating progression to failure and increasing therisk of sudden cardiac death. This review article highlights the specificcardio-renal oxidative stress in CKD and provides an understanding of thepathophysiology and impact of uraemic toxins, inflammation, and anaemia onoxidative stress...ReadMore">


21 Nov | Categories : Hematology Start a topic Comment Mail Share Download
Chronic myelomonocytic leukemia (CMML) is acomplex clonal hematological disorder classified among myelodysplastic (MDS)/myeloproliferative neoplasms. Prognosis is poor and there is a lack ofeffective treatments.  Thehypomethylating agent decitabine has shown activity against MDS and elderlyacute myeloid leukemia, but there is little data focusing specifically on itsefficacy in CMML.  An open-label phase 2was carried out to assess the efficacy and safety of decitabine in Italian CMMLpatients...ReadMore">


21 Nov | Categories : Hematology Start a topic Comment Mail Share Download
Despite majorimprovements in the treatment landscape, most multiple myeloma (MM) patientseventually succumb to the underlying malignancy. Immunotherapy represents an attractivestrategy to achieve durable remissions due to its specificity and capacity forlong term memory.   There remains anunmet need to better understand the immunologic effects of checkpoint blockade,delineate mechanisms of resistance to these therapies and identify optimalcombination of agonistic signaling, checkpoint inhibitors as well as other therapies includingCAR-Ts, to realize the potential of the immune system to control and preventMM...ReadMore">


21 Nov | Categories : Hematology Start a topic Comment Mail Share Download
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21 Nov | Categories : Hematology Start a topic Comment Mail Share Download
The need forharmonization in the diagnosis and scoring of GvHD has been recognized for manyyears and several other attempts have been made to improve this by the use ofelectronic tools but generally without success. The eGVHD App is availableeverywhere and could be used by any practitioner. The App could be ofparticular interest to HPCs with limited GvHD experience and can also be usedfor training. It remains to be seen whether the use of the eGVHD App, byimproving the grading of GvHD in daily practice, could have an impact onclinical decisions and transplant outcomes...ReadMore ">


20 Nov | Categories : Endocrinology Start a topic Comment Mail Share Download
endocrine system can cause varied changes in physiological hair growthand cycling. Diagnosis and treatment of these disorders require amultidisciplinary approach involving a dermatologist, gynecologist and anendocrinologist. In this review, we briefly discuss the influence of hormoneson the hair cycle and hair changes in various endocrine disorders...ReadMore">


19 Nov | Categories : Endocrinology Start a topic Comment Mail Share Download
This consensusstatement provides the guidance/recommendations for Indian practitionersregarding the use of OCP in women with PCOS. PCOS is one of the commonendocrinopathies encountered in gynecological/endocrine practice.The spectrum of this disorder may range from prepubertal girls with prematurepubarche, young girls with hirsutism, acneand anovulatory cycles, married women with infertility, and elderly women.Although obesity is a common feature for most PCOS patients, 'lean PCOS' alsoexists. For several years, OCPs have played an important role in the symptommanagement of PCOS women. This is due to the fact that OCPs decrease theluteinizing hormone, reduce androgen production, and increase sexhormone-binding globulin, which binds androgens. Several new formulations ofOCPs have been developed to decrease the side effects. This includes use ofless androgenic progestins and lower doses of ethinyl estradiol. Theseconsensus recommendations help the health provider to choose the right type ofOCPs, which will alleviate the symptoms with least side effects. It also givesinsight into the indications, contraindications, and concerns regarding itsshort, intermediate and long-term use...ReadMore">


19 Nov | Categories : Endocrinology Start a topic Comment Mail Share Download
Antidiabetic drugs (OADs) are increasingly prescribedto treat hyperglycaemia during pregnancy in women with gestational diabetesmellitus (GDM) or polycystic ovary syndrome (PCOS), eventhough long-term effects on offspring are unknown. A systematic reviewsummarises the evidence of follow-up studies of randomised controlled trials(RCTs) reporting on long-term effects of prenatal exposure to OADs onoffspring.   

Onthe basis of this systematic review, there is evidence suggesting increasedoffspring weight in childhood after maternal metformin use during gestation.The clinical implication of this finding remains unclear, since we do not haveevidence on whether a minor effect on weight in these metformin-exposedchildren increases their risks of metabolic diseases like obesity, insulinresistance or diabetes in adolescence and later life...ReadMore ">