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Thecomparative effectiveness of commonly used conservative treatments for carpal tunnel syndrome has not been evaluatedpreviously in primary care. This randomised, open-label, pragmatic trial aimedto compare the clinical and cost-effectiveness of night splints with acorticosteroid injection with regards to reducing symptoms and improving handfunction in patients  with mild ormoderate carpal tunnel syndrome....ReadMore ">


15 Nov | Categories : Orthopedics Start a topic Comment Mail Share Download
Accurate diagnosisof carpal tunnel syndrome (CTS), themost common entrapment neuropathy, and its differentiation from other diseasesare essential, especially in older individuals with advanced symptoms andmodified electrophysiological abnormalities. The current study was conducted toevaluate the diagnostic accuracy of ultrasonography (US), regarding sensitivityand specificity in the diagnosis of CTS in elderly patients....ReadMore">


15 Nov | Categories : Orthopedics Start a topic Comment Mail Share Download
Rheumatoidarthritis (RA) is achronic, inflammatory disease that affects 1% of the general population.Fatigue is a common complaint of patients with RA, however their perceivedfatigue may be more exacerbated than objective measures of fatigue mayindicate. The assessment of fatigue is made complex due to inconsistent andvague terms used to define fatigue, and the task dependence offatigability.  In order to offer someclarity to the manifestation of fatigue in clinical populations, this reviewoutlines that fatigue should be described with subsections that are related tothe symptom, such as: perceived fatigability and performance fatigability. Thisreview also describes RA and the various neuromuscular changes associated withthe disease that can lead to alterations in both perceived and performancefatigue....ReadMore ">


15 Nov | Categories : Orthopedics Start a topic Comment Mail Share Download
A 12-month noninterventional, observationalstudy was conducted in adult patients with RA)to observe patterns of use of the interleukin-6 receptor-alpha inhibitortocilizumab in routine clinical practice...ReadMore ">
Osteoarthritis (OA) is a highly debilitating joint disease thatcauses progressive, irreversible damage to articular cartilage. OA takes amassive toll on society that has grown in recent decades, but no therapy hasbeen shown to halt or reverse the progression of the disease. The critical needfor better treatments and increased interest cellular therapies has spawned anew generation of "minimally manipulated" cell treatments. Autologousadipose tissue injections are among the most controversial of these newtreatments. Despite a lack of clinical evidence, adipose tissue injections areoften marketed as "stem cell" injections with wide-rangingregenerative benefits. The purpose of this study is to estimate the effect sizeof the treatment by comparing the efficacy of autologous fat to hyaluronic acid(HA)...ReadMore ">


14 Nov | Categories : Nephrology Start a topic Comment Mail Share Download
Approximately 90% of all UTIs in young women arecaused by E. coli which is a gram-negative, rod-shaped bacterium and a memberof the normal intestinal microorganism.  The current study was conducted to determineantibiotic resistance and genotyping of uropathogenic E. coli strains isolatedfrom the patients with urinary tract infections in Tehran...ReadMore">


14 Nov | Categories : Nephrology Start a topic Comment Mail Share Download
Obstructivenephropathy (ON) secondary to the congenital hydronephrosis (HN) is one of themost common causes of chronic kidney disease in children. Neither currentlyused imaging techniques nor conventional laboratory parameters are sufficientto assess the onset and outcome of this condition; hence, there is a need toprove the usefulness of newly discovered biomarkers of kidney injury in thisrespect. The purpose of the study was to assess the urinary excretion ofalpha-GST, pi-GST, NGAL, and KIM-1 and the serum level of NGAL in children withcongenital unilateral hydronephrosis secondary to ureteropelvic junctionobstruction. The results were evaluated in relation to severity of HN, thepresence of ON, relative function of an obstructed kidney, and the presence ofproteinuria...ReadMore">


14 Nov | Categories : Nephrology Start a topic Comment Mail Share Download
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14 Nov | Categories : Nephrology Start a topic Comment Mail Share Download
kidney disease (CKD), as well as in CKD animalmodels, and kidney transplantdonors have a greater risk of end-stage renal disease than healthy controls. However,whether or not the intrarenal RAS is activated immediately after kidney donation in kidney transplant donors is unclear, andthe mechanism underlying intrarenal RAS activation is unknown.  The present study was performed to clarifywhether or not urinary plasma angiotensinogen (AGT) excretion, which reflectsthe intrarenal RAS, increases immediately after kidney donation in kidney transplantdonors who have no existing renal damage.  Also, investigated the factors associated withintrarenal RAS activation....ReadMore">


14 Nov | Categories : Nephrology Start a topic Comment Mail Share Download
There is growing evidencethat nonalcoholic fatty liver disease (NAFLD) is associated with ahigher risk of urolithiasis, but it has not yet been determined that thisassociation is reproducible and consistent across different studies. Thepresent systematic review and meta-analysis investigated the association between NAFLD andthe risk of urolithiasis,representing a comprehensive assessment of this association to date. Thedata provide evidence suggesting an increased riskof urolithiasis among patients with NAFLD.... ReadMore">