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Acute Subdural Hematoma Evacuation: Predictive Factors of Outcome.


1 Nov | Categories : Neurosurgery Start a topic Comment Mail Share Download
Abstract: Acute subduralhematoma (aSDH) is a major cause of admission at Neurosurgical EmergencyDepartment. Nevertheless, concerns regarding surgical indication in patientswith multiple comorbidities, poor neurological status, antithrombotic therapy, andolder age still persist. Therefore, a correct recognition of predictive outcomefactors at hospital discharge is crucial to an appropriate neurosurgicaltreatment. ReadMore

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Utility of Computed Tomography-guided Biopsy in Evaluation of Metastatic Spinal Lesions.


1 Nov | Categories : Neurosurgery Start a topic Comment Mail Share Download
plasmacytoma, 40% had metastatic carcinomas, 6.66% had non-Hodgkin's lymphoma, and 3.33% had small round cell tumor.ReadMore">

Prognostic factors determining poor postsurgical outcomes of mesial temporal lobe epilepsy.


1 Nov | Categories : Neurosurgery Start a topic Comment Mail Share Download
Abstract: The rate of complete remission of seizures afterepilepsy surgery for mesial temporal lobe epilepsy (MTLE) is only 60% to 70%. Almostone third of patients continue to have seizures after surgery. The long-termoutcome is worse than the short-term outcome, with 48 to 58 percent continuingto experience seizures 5 years after surgery.  It is important to develop reliable predictorsof surgical outcomes for MTLE and selecting proper surgical candidates remainsa challenge.  This study was conducted toinvestigate the long-term postoperative outcomes and predictive factorsassociated with poor surgical outcomes in mesial temporal lobe epilepsy (MTLE).ReadMore">

Surgical Treatment of Vascular Intramedullary Spinal Cord Lesions.


1 Nov | Categories : Neurosurgery Start a topic Comment Mail Share Download
hemangioblastomas, and arteriovenous malformations (AVM). These lesions are each unique and the literature pertaining to their surgical management is largely limited to retrospective case series and case reports. It is imperative to appreciate, separately, the unique angioarchitecture of each lesion, as well as their natural history, symptomatic presentation, diagnosis, indications for surgery, and surgical outcomes. Herein the authors present a clinical case series of the surgical management of intramedullary spinal cord cavernous malformations, hemangioblastomas, and intramedullary arteriovenous malformations over a 17-year period at a single institution.ReadMore">

Early prediction of acute kidney injury using serum phosphorus as a biomarker in pediatric cardiac surgical patients.


30 Oct | Categories : Nephrology Start a topic Comment Mail Share Download
biomarkers for predicting AKI has hampered the ability to take therapeutic measures for preventive cause.  A prospective diagnostic observational study of 51 children aged between 3 weeks and 12 years undergoing elective cardiac surgery in a tertiary care center was carried out to find out the role of serum phosphorus in prediction of AKI as a biomarker after cardiac surgery in children.ReadMore">

A Randomized Controlled Trial of Topical Application of Tranexamic Acid in Patients with Thoracolumbar Spine Trauma Undergoing Long-Segment Instrumented Posterior Spinal Fusion.


30 Oct | Categories : Neurosurgery Start a topic Comment Mail Share Download
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Fluorescence Guided Surgery with 5-Aminolevulinic Acid for Resection of Spinal Cord Ependymomas.


30 Oct | Categories : Neurosurgery Start a topic Comment Mail Share Download
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New Perspectives in Iron Chelation Therapy for the Treatment of Neurodegenerative Diseases


30 Oct | Categories : Neurology Start a topic Comment Mail Share Download
synuclein (Lewy bodies). The movement disorder of PD occurs largely due to loss of dopaminergic neurons of the substantia nigra, resulting in striatal dopamine depletion. There are currently no proven disease modifying treatments for PD, with management options consisting mainly of dopaminergic drugs, and in a limited number of patients, deep brain stimulation. Long-term use of established dopaminergic therapies for PD results in significant adverse effects, and there is therefore a requirement to develop better means of restoring striatal dopamine, as well as treatments that are able to slow progression of the disease. Here, authors discuss the promising regenerative cell-based and gene therapies, designed to treat the dopaminergic aspects of PD whilst limiting adverse effects, as well as novel approaches to reducing ?-synuclein pathology.ReadMore">

Nonalcoholic fatty liver disease is associated with increased hemoconcentration, thrombocytopenia, and longer hospital stay in dengue-infected patients with plasma leakage.


30 Oct | Categories : Infectious Disease Start a topic Comment Mail Share Download
Abstract:  A prominent histopathological feature offatal dengue cases is hepatic steatosis. However, the association betweenhepatic steatosis and dengue severity is unknown. A retrospective study wasconducted to determine the associations of nonalcoholic fatty liver disease(NAFLD) with laboratory markers of dengue severity and length of hospital stay(LOS). ReadMore ">

Osteogenic niche in the regulation of normal hematopoiesis and leukemogenesis


30 Oct | Categories : Hematology Start a topic Comment Mail Share Download
Abstract:  The bone marrow microenvironment, also knownas the bone marrow niche, is a complex network of cell types and acellularfactors that supports normal hematopoiesis. Recent evidences have shown that acute myeloid leukemia cells induceosteogenic differentiation in mesenchymal stromal cells to gain a growthadvantage. This review discusses about the role of the osteogenic niche in themaintenance of hematopoietic stem and progenitor cells, as well as theirtransformation into leukemia cells. Also, discussed the signaling pathways thatregulate osteogenic nichehematopoietic stem and progenitor cells or osteogenicniche-leukemic stem/initiating cell interactions in the bone marrow, togetherwith novel approaches for therapeutically targeting these interactions.ReadMore

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