Primary Central Nervous System Germ Cell Tumors: A Review and Update

Nov 13 2018 , India
Mumbai

Primarycentral nervous system (CNS) germ cell tumors (GCT) are a heterogeneous groupof tumors that are still poorly understood. In North America, GCTs compriseapproximately 1% of primary brain tumors in pediatric and young adult patients.GCTs can occur as pure or mixed subtypes; they are divided into germinomas,which are the most common subtype, and non-germinomatous germ cell tumors(NGGCTs), which consist of approximately one-third of GCTs and includeteratomas, embryonal carcinomas, choriocarcinomas, and yolk sac tumors.  The current literature is reviewed to discussthe pathophysiology, clinical presentation, assessment and diagnosis,treatment, molecular biology, and prognosis of primary CNS GCTs.ReadMore

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